General Hospital (GH) spoilers suggest some stunning plot twists ahead, so fans need to brace themselves for a massive bombshell. However, fans have already been shocked by the news that Kelly Monaco was fired and is on her way out of the soap.

It sounds like Sam will be killed off, and while it has been reported that the character will exit this fall, there are also online rumors circulating that Monaco is set to exit sooner rather than later.

Autumn officially begins on Sunday, September 22nd, but may mark the end of the Labor Day weekend as the unofficial start to fall, so could Sam and Kelly’s exit start to unravel as early as the week of September 2-6?

The news that Nikolas Cassadine (Adam Huss) is an ineligible donor for Lulu Spencer’s (last played by Emme Rylan) liver transplant hit Laura Collins (Genie Francis) hard during the Tuesday, August 27 episode.

She’s now more desperate than ever to find Lucky Spencer (Jonathan Jackson) as she believes he’s Lulu’s only hope. So much so, that she’ll turn to the WSB for help.

It won’t take long for the agency to pinpoint Lucky’s location and bring him back home. He’ll likely be tested immediately, but will he be the one to save the day for his sister?

It would be a real nail-biter if Lucky was brought back to Port Charles, only to find out he wasn’t a match or was ineligible for the liver transplant.

After all, he couldn’t help with Lulu’s bone marrow surgery all those years ago, which is why Nikolas was brought in. How is it possible he can help now?

Still, as many residents in the little town are currently getting tested on the off chance, they could be a match to save Lulu, fans should expect a plot twist with this storyline.

Could Sam end up being a match? She’d rush to help Lulu out, not only because it’s in her nature, but also because of the strong relationship she has with Rocco Falconeri (Finn Francis Carr).

Add in the mixed emotions Dante Falconeri (Dominic Zamprogna) has for both women, and this could make for an interesting, yet sticky, storyline.

Viewers may also recall that Laura mentioned to Nik during her prison visit on Tuesday (before the results came in) that there are major risks to surgery of this nature.

If Sam’s a donor match for Lulu, could she end up losing her life trying to save Lulu?

General Hospital spoilers imply that Sam McCall could have a tragic ending in Port Charles, as her storyline winds to a close.

The very fact that Sam could die so that Lulu can live would stir up a ton of complicated feelings for Dante, and GH fans.

Plus, with all that’s going on with the Davis girls, Alexis Davis (Nancy Lee Grahn) could spiral into a dark place.

Fans need to buckle up for a bumpy road in PC ahead!